Protein folding begins in the cytosol, where secondary structural elements interact with the solvent, entropy loss drives folding from disorderly state toward a molten globule state and defined tertiary structure.

Explore the SCOP database and its manually curated protein structure classification by class, fold, super-family, and family, including seven major classes and the concept of domains.

Explore CATH, a manually curated structural database that classifies proteins using class, architecture, topology, and homologous super-family based on secondary structure content.

Predict protein structures from known homologues using protein homology modeling, a structural bioinformatics technique that links structure to function and complements experimental methods like X-ray crystallography, NMR, and electron microscopy.

Explore protein molecular dynamics by simulating motion with newtonian equations, using initial coordinates from x-ray crystallography, nmr, or electron microscopy, and evolving trajectories to reveal equilibrium behavior in biophysical environments.

Protein molecular docking is a bioinformatics technique in structure-based drug design, where known target and ligand structures are examined for binding, with binding energy calculations evaluating interaction strength.