Mastering Immunology - a Comprehensive Course

Explore how MHC class I and class II present intracellular and extracellular antigens, triggering cytotoxic and helper T cell responses, with APCs like dendritic cells and macrophages.

Learn how complement proteins activate via C3 and C4 pathways to tag pathogens, promote inflammation, and assemble the membrane attack complex that destroys microbes, with regulation and alternate pathways.

Mastering immunology explains how dendritic cells present antigens via MHC II to helper T cells and activate CD8 killer T cells, coordinating the adaptive response and memory formation.

Explore how B cells bind antigens with their receptor, receive CD4+ T cell help, and mature into plasma cells that secrete antibodies, neutralizing pathogens and activating memory responses.

Explore how T cells diversify through alpha-beta and gamma-delta TCRs, V(D)J recombination, thymic selection with MHC antigen, and CD4/CD8 fate, shaped by dendritic cells.

Trace T-cell selection in the thymus—from double negative to single positive—via Notch cues and MHC class I/II, while acknowledging B cell–driven antibody diversity and memory responses.

Explore how MHC class I and II diversity shapes antigen presentation by antigen presenting cells and the CD4/CD8 T cell response, including co-stimulation via CD28 and B7.

Explore how macrophages and neutrophils act as innate key players, signaling through Jak-STAT, NF-kappa B, and TLR pathways, shaping cancer immunity via M1/M2 states and tumor-associated macrophages.

Explore how B cells activate with or without T helper cells, form germinal centers, and switch antibody classes to neutralize pathogens and enable opsonization and NK activation.

Explore how CD4 and CD8 T cells activate with CD28 co-stimulation and autocrine IL-2, driving clonal expansion. See how Th1/Th2/TFH/Th17 guide macrophages, B cells, and cytotoxic killing.

Explore how mucosal immunity samples pathogens via M cells, presents antigens through dendritic cells, and primes adaptive responses at the oral mucosa and teeth with the mucosal microbiome and Tregs.

Explore how pathogens evade immunity through MHC disruption, TLR interference, complement disruption, and antigenic modification, and examine primary and acquired immunodeficiencies, with HIV and autoimmunity as key examples.

Examine how autoimmunity and allergies arise from autoreactive T and B cells, HLA predispositions, epitope cross-reactivity, and mast cell driven allergic responses.

Investigate how MHC and HLA matching shapes transplant rejection and graft-versus-host risk in bone marrow and organ transplants. Examine cancer immunology and therapies, including immunotherapy and monoclonal antibodies.