
Introduction to the course.
A general overview of the course.
Overview of the download and installation process for UCSF Chimera.
An overview of the download and installation process for PyMOL.
Recap of all Section 1 topics
Introduction to protein structure and function
A brief introduction to X-Ray crystallography.
An introduction to NMR spectroscopy.
An introduction to the RCSB PDB Database.
Recap of Section 2 topics.
An introduction to homology modeling
Tutorial of Swiss-Model.
An introduction to homology modeling with Phyre2.
An introduction to structure validation with QMEAN
A recap of the topics covered in Section 3: Homology Modeling
An introduction to molecular docking.
An tutorial of the SPOT-Ligand2 software for molecular docking
Tutorial of the ZINC Database
Recap of Section 4 topics.
An overview of possible future steps for this course.
Introduction to bonus sections and DOCK6
Installation of DOCK6
Tutorial of protein preparation for docking.
Tutorial of sphere generation in DOCK6
Tutorial of generating a grid in DOCK6
Docking tutorial
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Content Overview
Suitable for anyone with basic biology knowledge, this course will take you through the world of structural biology and how bioinformatics has the power to change the face of medicine and healthcare.
Starting with the basics of structural biology, this course will help you embrace the way that structural bioinformaticians think and operate, providing you with the necessary approach to tackling complex biomedical issues.
With these basics mastered, the course will take you through selecting a protein of interest that will both give you the motivation to see your project come to fruition and yield results. With your protein of focus in hand, this course will then guide you through homology modeling, docking, and even protein-ligand interaction analysis.
Students completing the course will have the knowledge to investigate a disease-associated protein from a structural biology point of view and will possess the necessary skills and data to form a research project of their own.
Content Overview
Suitable for anyone with basic biology knowledge, this course will take you through the world of structural biology and how bioinformatics has the power to change the face of medicine and healthcare.
Starting with the basics of structural biology, this course will help you embrace the way that structural bioinformaticians think and operate, providing you with the necessary approach to tackling complex biomedical issues.
With these basics mastered, the course will take you through selecting a protein of interest that will both give you the motivation to see your project come to fruition and yield results. With your protein of focus in hand, this course will then guide you through homology modeling, docking, and even protein-ligand interaction analysis.
Students completing the course will have the knowledge to investigate a disease-associated protein from a structural biology point of view and will possess the necessary skills and data to form a research project of their own.