Structural Biology 101: A Beginner's Guide
- Basic biology knowledge (i.e. first-year high school biology) is recommended
Learn all about Structural Biology and walk away with the hard skills to conduct your own original research!
Get access to valuable tutorials, lectures, and articles that will grant you the knowledge to become comfortable in the field of Structural Biology for FREE!
Suitable for anyone with basic biology knowledge, this course will take you through the world of structural biology and how bioinformatics has the power to change the face of medicine and healthcare.
Starting with the basics of structural biology, this course will help you embrace the way that structural bioinformaticians think and operate, providing you with the necessary approach to tackling complex biomedical issues.
With these basics mastered, the course will take you through selecting a protein of interest that will both give you the motivation to see your project come to fruition and yield results. With your protein of focus in hand, this course will then guide you through homology modeling, docking, and even protein-ligand interaction analysis.
Students completing the course will have the knowledge to investigate a disease-associated protein from a structural biology point of view and will possess the necessary skills and data to form a research project of their own.
- Motivated individuals who are looking for ways to broaden their knowledge and explore protein behavior and composition using technology at no cost
- Course Outline00:53
- Getting Set Up: Chimera06:17
- Getting Set Up: PyMOL07:48
- Section 1 Recap01:47
- Protein Basics04:51
- Intro to X-Ray Crystallography00:54
- Intro to NMR Spectroscopy01:26
- RCSB PDB Database12:22
- Section 2 Recap03:43
- Intro to Homology Modeling02:22
- Modeling with Swiss-model09:27
- Modeling with Phyre2.011:16
- Verifying Structures with QMEAN15:50
- Section 3 Recap01:36
- Intro to Docking03:14
- Docking with SPOT-Ligand208:23
- Exploring the ZINC Database08:35
- Section 4 Recap04:43
- Future Steps16:05
- Course Conclusion00:48
- Content Copyright and Acknowledgements00:15
- Intro to DOCK604:15
- Installing DOCK602:43
- Protein Preparation02:26
- Surface Sphere Generation03:23
- Grid Generation03:58
Saaim Khan is a student at Cranbrook Kingswood Upper School in Bloomfield Hills, MI. He is deeply passionate about spreading research education to the public and has received recognition for multiple personal research projects. He teaches computational biology to students at his high school and has consolidated courses that will not only help you learn conceptual basics but also empower you with the tools to complete research projects of your own.