Structural Biology 101: A Beginner's Guide

Learn all about structural biology and its fascinating applications to research, medicine, healthcare, and more!
New
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46 students
Structural Biology 101: A Beginner's Guide
New
Rating: 0.0 out of 5 (0 ratings)
49 students
How to build and analyze macromolecular protein structures using computational tools

Requirements

  • Basic biology knowledge (i.e. first-year high school biology) is recommended
Description

Learn all about Structural Biology and walk away with the hard skills to conduct your own original research!

Get access to valuable tutorials, lectures, and articles that will grant you the knowledge to become comfortable in the field of Structural Biology for FREE!

Content Overview
Suitable for anyone with basic biology knowledge, this course will take you through the world of structural biology and how bioinformatics has the power to change the face of medicine and healthcare.

Starting with the basics of structural biology, this course will help you embrace the way that structural bioinformaticians think and operate, providing you with the necessary approach to tackling complex biomedical issues.

With these basics mastered, the course will take you through selecting a protein of interest that will both give you the motivation to see your project come to fruition and yield results. With your protein of focus in hand, this course will then guide you through homology modeling, docking, and even protein-ligand interaction analysis.

Students completing the course will have the knowledge to investigate a disease-associated protein from a structural biology point of view and will possess the necessary skills and data to form a research project of their own.

Who this course is for:
  • Motivated individuals who are looking for ways to broaden their knowledge and explore protein behavior and composition using technology at no cost
Course content
6 sections • 28 lectures • 2h 28m total length
  • Introduction
    05:17
  • Course Outline
    00:53
  • Getting Set Up: Chimera
    06:17
  • Getting Set Up: PyMOL
    07:48
  • Section 1 Recap
    01:47
  • Protein Basics
    04:51
  • Intro to X-Ray Crystallography
    00:54
  • Intro to NMR Spectroscopy
    01:26
  • RCSB PDB Database
    12:22
  • Section 2 Recap
    03:43
  • Intro to Homology Modeling
    02:22
  • Modeling with Swiss-model
    09:27
  • Modeling with Phyre2.0
    11:16
  • Verifying Structures with QMEAN
    15:50
  • Section 3 Recap
    01:36
  • Intro to Docking
    03:14
  • Docking with SPOT-Ligand2
    08:23
  • Exploring the ZINC Database
    08:35
  • Section 4 Recap
    04:43
  • Future Steps
    16:05
  • Course Conclusion
    00:48
  • Content Copyright and Acknowledgements
    00:15
  • Intro to DOCK6
    04:15
  • Installing DOCK6
    02:43
  • Protein Preparation
    02:26
  • Surface Sphere Generation
    03:23
  • Grid Generation
    03:58
  • Docking
    03:54

Instructor
High School Student
Saaim Khan
  • 4.5 Instructor Rating
  • 102 Reviews
  • 2,391 Students
  • 2 Courses

Saaim Khan is a student at Cranbrook Kingswood Upper School in Bloomfield Hills, MI. He is deeply passionate about spreading research education to the public and has received recognition for multiple personal research projects. He teaches computational biology to students at his high school and has consolidated courses that will not only help you learn conceptual basics but also empower you with the tools to complete research projects of your own.