Preformulation Studies for Pharmaceutical Industry

Preformulation studies are very important for the development of a pharmaceutical dosage forms in the pharmaceutical industry. This course will help you to understand preformulation development approach with basic concepts of preformulation studies of the Pharma Industry.

Each drug substance has intrinsic chemical and physical characteristics that must be considered before the development of a pharmaceutical formulation. Drug product is formulated using the information gained during the preformulation studies and with the  consideration of the dose or doses, dosage form, and route of administration desired for the clinical studies and for the proposed marketed product. Pharmaceutics includes the scientific and technological aspects of the design, compounding, and manufacture of dosage forms.

In the scope of this course, most important physicochemical properties of the drug substance such as solubility, permeability, ionization constant, crystality, polymorphism, amorphous, particle size, particle shape, particle surface area and bulk tapped density & flow evaluation have been discussed.

These aspects in the design of dosage forms are discussed in the scope of this course.

COURSE CONTENT

Physicochemical Properties of the Drug Substance

• Topic 1: Solubility

• Topic 2: Permeability

• Topic 3: Ionization Constant

• Topic 4: Crystality

• Topic 5: Polymorphism

• Topic 6: Amorphous

• Topic 7: Particle Size

• Topic 8: Particle Shape

• Topic 9: Particle Surface Area

• Topic 10: Bulked Tapped Density & Flow Evaluation