Pharmacokinetics Masterclass: Applications in Practice

Name: Pharmacokinetics Masterclass: Applications in Practice
Rating: 4.6 (18 reviews)

Clinical Pharmacokinetics, a guide for pharmacists and technicians to pass NAPLEX, GPhC, PEBC, FPGEE and KAPS exams

Created byBedeer Elsherbiny

Last updated 8/2025

English

English [Auto],

What you'll learn

How to adjust drug doses using pharmacokinetics
Real clinical case studies with worked examples
PK parameters explained clearly for practice
When and how to use TDM in pharmacy settings
Dosage regimen design and time-to-steady-state
Nonlinear vs linear pharmacokinetics

Course content

8 sections • 54 lectures • 3h 17m total length

Course Structure & Clinical Pharmacokinetics9:23
Discover clinical pharmacokinetics across seven modules, covering ADME, key parameters (clearance, volume of distribution, half-life), dosing strategies, therapeutic drug monitoring, and renal function-based dose adjustments.
Importance in Pharmacy3:03
Key Pharmacokinetic Parameters20:20
Explore core pharmacokinetic parameters, including area under the curve, bioavailability, volume of distribution, clearance, half-life, Cmax and Tmax, and how they guide dosing and steady-state planning.
Pharmacist Role4:07
Module 1 Quiz
Module 1 Flashcards Practice with the link below
Module Handout

Bioavailability (F)9:40
Explore how bioavailability (F) determines how much oral drug reaches circulation, compare oral and IV AUC, adjust doses to match IV exposure through case studies.
Distribution4:53
Volume of Distribution (Vd)7:16
Metabolism & Albumin7:06
Clearance (Cl)7:04
Half-life (t½)14:31
Learn how half-life t½ governs dosing intervals and time to steady state using the elimination rate constant k and the 0.693/k rule, with first-order versus zero-order kinetics.
Case Studies4:51
Module 2 Flashcards Practice with the link below
Module 2 Quiz
Module 2 Flashcards
Module 2 Handout

Indications for TDM4:24
When to apply TDM3:56
Interpreting Results1:11
Compare results to therapeutic ranges and free versus total drug levels, phenytoin and valproate. Use lab data with symptoms and renal and liver function to guide response and adjust dosing.
Special Populations2:14
Adjust doses for renal impairment using creatinine clearance to prevent accumulation. Monitor hepatic impairment effects on phenytoin and theophylline; reduce doses for pediatric, geriatric, and critically ill patients in ICU.
Case Studies6:39
Module 4 Quiz
Module 4 Flashcards Practice with the link below
Module 4 Handout

Digoxin3:57
Analyze the pharmacokinetics of special drugs, focusing on digoxin, and learn how absorption, distribution, metabolism, and renal function shape toxicity risk and therapeutic levels.
Lithium1:47
Explore lithium's narrow therapeutic index, maintenance and acute dose ranges, kidney-driven elimination, 12-hour post-dose monitoring, toxicity signs, and drug interactions that alter sodium and lithium levels.
Phenytoin1:20
Phenytoin shows saturable pharmacokinetics with zero-order kinetics after saturation; therapeutic range is 10–20 mcg/mL, free level 1–2 mcg/mL, and albumin binding affects levels, with toxicity causing ataxia, nystagmus, and confusion.
Warfarin1:34
Theophylline0:58
Theophylline pharmacokinetics encompass a 10–20 µg/mL target range and CYP1A2 metabolism. Smoking and age affect clearance; monitor levels during dose changes or illness to prevent toxicity like tremors, seizures, tachycardia.
Gentamicin- Vancomycin2:42
Carbamazepine Valproate& other drugs2:11
Case Studies7:34
Explore case studies to evaluate pharmacokinetic interactions such as carbamazepine's enzyme induction reducing valproate levels, carbamazepine autoinduction, and hepatic impairment's impact on clearance, guiding targeted dosing and monitoring.
Module 5 quiz
Module 5 Flshcards
Module 5 Handout

Estimation of Renal Function2:47
Renal Impairment AKI versus CKD2:22
Explore how renal impairment alters pharmacokinetics, including decreased clearance, longer half-life, shifts in volume of distribution and protein binding changes in uremia, with AKI vs CKD dosing and monitoring.
Dose Adjustment& Special Population3:23
Case Studies4:48
Explore case studies on adjusting drug doses for renal impairment using creatinine clearance, including gentamicin dose reduction to 55% of normal and digoxin dosing in CKD stage three.
Module 6 Quiz
Module 6 Flashcards
Module Handout

Non-linear versus linear Kinetics4:43
Explore linear versus non-linear pharmacokinetics, illustrating saturation in metabolic processes, zero-order and first-order kinetics, and dose-concentration relationships with case studies on toxicity risks.
Pharmacokinetic Drug-Drug Interactions1:24
Concentration versus time dependent killing3:05
Pharmacokinetic Variability2:46
Case Studies7:55
Bayesian case studies on dose adjustments for kidney- and protein-binding–related pharmacokinetic changes, highlighting free phenytoin monitoring, gentamicin and vancomycin trough targets, theophylline toxicity, and carbamazepine autoinduction.
Module 7 Quiz
Module 7 Flashcards
Module Handout

Requirements

A laptop, desktop, or tablet with internet access to stream video lessons and download worksheets
Access to a calculator for PK calculations (online or scientific)
Basic understanding of human physiology and pharmacology
Familiarity with common drug classes (e.g., antibiotics, antiepileptics, cardiovascular drugs)
No advanced clinical experience is required.
Optional: Prior exposure to concepts like half-life, clearance, and bioavailability

Description

Clinical Pharmacokinetics is a focused, application-driven course designed for pharmacy students, pharmacists, and pharmacy technicians who want to deepen their understanding of how drugs behave in the body. The course will cover essential pharmacokinetic principles and equip learners with the skills to optimise drug therapy through individualised dosing and therapeutic drug monitoring (TDM).

The course will cover concepts such as absorption, distribution, metabolism, and excretion (ADME); the course progresses to advanced topics including volume of distribution (Vd), clearance (Cl), half-life (t½), bioavailability (F), area under the curve (AUC), and steady-state concentration (Css). Learners will also explore dosing interval (τ), accumulation, non-linear kinetics, concentration- versus time-dependent killing, and the design of dosage regimens.
Special attention will be given to pharmacokinetic variability, renal and hepatic function, dose adjustment in special populations, and other special pharmacokinetic topics.

You will have access to

Seven modules (Video presentation, module handout, quizzes)
Flashcards for each module
Final Practice Test
Case studies

By the end of this course, learners will be able to apply pharmacokinetic concepts confidently in clinical settings to support safe, effective, and evidence-based patient care. The course is also a valuable resource for exam preparation, including GPhC, NAPLEX, KAPS, and other international pharmacy licensing assessments

Who this course is for:

Clinical and community pharmacists
Pharmacy students preparing for exams or practice
Technicians aiming to understand PK concepts
International pharmacists pursuing PEBC/PSA/NAPLEX/GPhC

Pharmacokinetics Masterclass: Applications in Practice

What you'll learn

Explore related topics

Course content

Module 1 Introduction6 lectures • 37min

Module 2 Pharmacokinetic Parameters and their clinical Use10 lectures • 55min

Module 3 Dosage Regimen Design7 lectures • 32min

Module 4 Therapeutic Drug Monitoring7 lectures • 18min

Module 5 Pharmacokinetics of key Drugs10 lectures • 22min

Module 6: Role of Kidney in Drug Elimination6 lectures • 13min

Module 7 Special Topics7 lectures • 20min

Clinical PK Practice Test1 lecture • 1min

Requirements

Description

Who this course is for: