Pharmaceutical Dosage forms

pharmaceuticals.

It is defined as a preparation devised to make possible administration of medications in measured orprescribed amount.Introduction of different dosage forms. Their classification with examples-their relative applications.

Familiarization with new drug delivery systems. Introduction to Pharmacopoeias with special reference to

the Indian Pharmacopoeia.

Pharmaceutics is the science of dosage form design.

There are many chemicals with known pharmacological properties but a raw chemical is of no use to a patient.

Pharmaceutics deals with the formulation of a pure drug substance into a dosage form.

Active Drug Substance(Active pharmaceutical ingredient -API)

Chemical compound with pharmacological (or other direct effect ) intended for use indiagnosis, treatment or prophylaxis of diseases.

International non-proprietary names (INN,generic names)

API handling can be difficult or impossible (e.g.,low mg ang doses)

Accurate drug dosing can be difficult orim possible

API administration can be impractical, unfeasible or not according to the therapeutic aims

Some API can benefit from reducing the exposure

to the environmental factors (light, moisture…), or

they need to be chemically stabilized due to than herent chemical instability

From drug substance to pharmaceutical preparation

Besides the choice of the active drug substance, you need to also make are responsible decision regardingthe route of administration and the DOSAGE FORM (drug delivery system)

wrong choice can cause failure of therapy

You should also be able to handle and administer the drug properly or advise the patient about i

wrong use can cause failure of therapy

Size separation-size separation by sifting. Official standards for powders. Sedimentation methods of size

separation. Construction and working of Cyclone separator.

Mixing and Homogenization-Liquid mixing and powder mixing, Mixing of semisolid. Study of silverson

Mixer-Homogenizer, planetary Mixer; Agitated powder mixer; Triple Roller Mill; Propeller Mixer, colloid

Mill and Hand Homogeniser. Double cone mixer.