
- Core study of Biochemistry
- Cellular function
- Genetic insights
- The impact of biochemistry in life
- Definition of biomolecules
- Definition of metabolism
- Definition of homeostasis
- What is CRISPR?
- How does it work?
- What should we expect in the near future?
- Structure of the atom
- The periodic table
Demonstrate the building blocks of matter by exploring atoms, isotopes, protons, neutrons, and electrons, and define molecules, elements, and compounds while illustrating how atoms bond to form everyday substances.
- Alkali metals
- Alkaline Earth metals
- Transition metals
- Halogens
- Noble gases
- Metalloids, gases, metals, nonmetals
- Definition of the Electron Configuration
- Levels and sublevels
- The Aufbau principle
- Quantum numbers
- Representation of the electron configuration
- Pauling Exclusion principle
- Hund's Rule
- Definition of the Skeletal structure
- Rules to draw skeletal structures
- Straight and branched chains
- Ring structures
- Definition of organic compounds
- Cyclic compounds
- Acyclic compounds
- Definition of Chemical bonds
- Ions
- Lewis structure
- Kelter strategy
- Ionic bonds
- Covalent bonds
- Polar and Non-polar bonds
- Metallic bonds
- Definition
- Benzene
- Stability due to resonance
- Equivalence of resonance structures
- Definition of hybridization
- Different types of hybridization
Examine how isomerism uses the same molecular formula to create different shapes, including structural and stereoisomers, with chirality guiding L amino acids, proteins, and enzymes.
- Introduction to biomolecules
- Functional groups
- Definition of hydrocarbons
- Prefixes and suffixes
- Types of hydrocarbons
- Definition of carbohydrates
- From carbohydrates to energy
- Classification of carbohydrates
- Structural diversity
- Functional significance
- Micelles and Lipid bilayer
- Cell membrane
Explore fatty acids as crucial lipid components with energy roles and amphipathic properties, and learn classification by saturation and essentiality, including oleic acid naming.
Explore simple versus mixed triglycerides and their glycerol backbone with three fatty acids. Understand saturation types, emulsification by bile salts, digestion by pancreatic lipase, and transport via chylomicrons.
Explore how cholesterol regulates membrane fluidity and is transported by LDL and HDL, through a case study of low cholesterol causing rigid membranes and nerve dysfunction.
- Compounds of amino acids: proteins
- Definition of Amino Acids
- Classification of Amino Acids
- Peptide bond
- Definition of Peptide
- Peptide bond in more detail
- Ramachandran plot
- Definition of Proteins
- Properties of Proteins
- Organization levels
- Protein denaturation
- Amino Acid analysis
- Edman's degradation
- Protein fragmentation
- What are protein secondary structures?
- Alpha helix and Beta sheet
- Non-periodic secondary structures
- EAK-16 II
- Key aspects
- Denaturation and reversibility
- Folding and Kinetic pathways
- Anfinsen's experiment
- Key aspects
- Examples
- Importance
Explore the structure of hemoglobin, a tetramer of two alpha and two beta chains with heme, and how cooperative binding and allosteric regulation adjust oxygen delivery.
Explore how lipid bilayer membranes and gatekeepers regulate molecular traffic through channels, carriers, and pumps, contrasting passive diffusion with energy-driven active transport.
This case study shows how the sodium-potassium pump uses ATP to export three sodium ions and import two potassium ions, creating gradients essential for nerve signals and muscle function.
- Definition of enzymes
- Factors that affect enzymes
- Cofactors
- Classification of enzymes
- Basic principles of enzyme kinetics
- Michaelis-Menten model
- General principles of enzyme catalysis
- Types of enzyme regulation
- Types of enzyme inhibition
- Kinetics and mechanism of hexokinase
- Regulation and inhibition
- Clinical relevance
- Differences between DNA and RNA
- Nucleotides
- Phosphodiester bond
- Nitrogenous bases
- Base pairing rules
- Key steps
- Enzymes involved in replication
- Key steps
- Regulation of transcription
- Significance
- Key steps
- Ribosomes and tRNA
- Importance of protein synthesis
- First Law of Thermodynamics
- Second Law of Thermodynamics
- Structure & Function of ATP
- Mechanisms of ATP Synthesis
- ATP hydrolysis and Energy release
- Role of ATP in Cellular processes
- Introduction to Metabolic Pathways
- Anabolic vs Catabolic Pathways
- Regulatory Mechanisms of Metabolism
- Importance of Metabolic Pathways in Cellular Function
- Importance of Glycolysis in Energy production
- Steps of Glycolysis
- Introduction to Gluconeogenesis
- Steps of Gluconeogenesis
- Regulation of Gluconeogenesis
- Importance of Gluconeogenesis
The pyruvate dehydrogenase complex in the mitochondrial matrix converts pyruvate to acetyl-CoA, linking glycolysis to the citric acid cycle, requiring five cofactors and tightly regulated by energy status.
Discover how fructose is metabolized in the liver, entering glycolysis downstream of pfk1, via fructokinase and aldolase B, and its links to lipogenesis and triglyceride production.
Explore the pentose phosphate pathway, a glycolysis branch that generates NADPH and ribose-5-phosphate, with oxidative and non-oxidative phases and the clinical impact of G6PD deficiency.
- Introduction to the Citric Acid Cycle
- Regulation of the Citric Acid Cycle
- Importance of the Citric Acid Cycle
- Steps of the Citric Acid Cycle
Explore how the electron transport chain drives ATP synthesis through proton pumping across the inner mitochondrial membrane, using NADH and FADH2, with oxygen as the final electron acceptor.
- Beta Oxidation Overview
- Process of Beta Oxidation
- Energy yield & Regulation of Beta Oxidation
Unlock the secrets of life at the molecular level with this comprehensive biochemistry course. Whether you’re a student preparing for exams or a biochemistry enthusiast, this course provides you with the essential knowledge needed to understand biochemistry and its real-world applications.
Why Choose This Course?
No prior general chemistry required: If you already have a solid understanding of chemistry, jump straight into the biochemistry content.
Hands-on learning: Apply concepts to real-world case studies and research scenarios.
Interactive Learning Experience: Engage with dynamic course materials, including interactive quizzes, real-world case studies, and practices, designed to deepen your understanding and make learning enjoyable and effective.
Flexible and Self-Paced: Study at your own pace, fitting the course into your schedule. Whether you're balancing school, work, or personal commitments, this flexible structure allows you to learn when it's convenient for you.
What You'll Learn:
Carbohydrates: Dive into the structure and function of carbohydrates as energy sources and vital building blocks for life.
Lipids: Discover how lipids form cell membranes and regulate cellular processes, impacting overall physiology.
Proteins: Explore protein structure from primary to quaternary levels. Learn cutting-edge techniques like amino acid analysis, Edman degradation, and protein synthesis.
Real-world applications: Analyze case studies like Anfinsen’s experiment and benzene resonance.
Enzyme Kinetics and Mechanisms: Master enzyme kinetics using the Michaelis-Menten model and explore enzyme regulation in metabolic processes.
Case study: Understand enzyme behavior through the hexokinase pathway.
DNA and RNA: Gain an in-depth understanding of DNA and RNA structure and function, covering genetic information storage, replication, transcription, and translation.
Metabolism: Understand ATP's role in cellular energy transfer. Learn the thermodynamics of pathways like glycolysis, the citric acid cycle, glucogenesis, and beta-oxidation, and how nutrients fuel life processes.
Ready to Master Biochemistry?
Join me on an exciting journey into the biochemical basis of life. Gain practical, real-world knowledge and boost your expertise with this engaging and accessible course. Enroll now and take your first step toward mastering the building blocks of life!