
Explore clinical enzymology through mbbs exam style mcqs, covering enzyme cofactors like pyridoxal phosphate, active sites, inhibition modes, isoenzymes, and key clinical biomarkers in myocardial infarction and liver disease.
Explore lipid chemistry basics, including storage forms like triacylglycerol, fatty acid types such as oleic acid and other monounsaturated or polyunsaturated fats, membrane lipids, phospholipids, sphingomyelin, and lipoprotein transport.
Explore core carbohydrate chemistry through MCQs on disaccharides, monosaccharides, aldose and ketose types, anomers, glycosidic linkages, and key polysaccharides such as hyaluronic acid and mucopolysaccharides.
Examine vitamins and nucleic acid chemistry, focusing on thiamine deficiency in chronic alcohol use and vitamin k-dependent gamma carboxylation. Explore folate trapping, leucovorin rescue, and DNA stability concepts.
Explore amino acid chemistry, protein structure and purification, including alpha helix rise of 0.5 nm, glucogenic and ketogenic amino acids, collagen glycine, purification techniques like salting out and ion exchange.
Explore carbohydrate metabolism and glycolysis regulation, including phosphofructokinase-1 activation by AMP, the impact of uncouplers on oxidative phosphorylation, and lactate formation in pyruvate dehydrogenase deficiency and thiamine-related conditions.
Review fats and lipid metabolism and fatty acid synthesis, highlighting citrate activation of acetyl-CoA carboxylase and malonyl-CoA formation. Discuss lipoprotein pathways and disorders, including apoB-48, MTTP, and lipoprotein lipase.
Explore amino acid metabolism and urea cycle disorders, including key enzymes like aspartate transaminase and carbamoyl phosphate synthetase, ornithine transcarbamylase deficiency, orotic aciduria, and diagnostic and treatment strategies.
Explore nucleotide metabolism, focusing on pyrimidine synthesis defects such as orotic aciduria from UMP synthase deficiency causing megaloblastic anemia, and purine metabolism disorders like Lesch-Nyhan syndrome with HGPRT deficiency.
Explore heme synthesis and degradation, including alas and plp dependence, porphyrias, iron absorption via dmt1, and the sickle cell mutation with methemoglobinemia.
Imagine seeing a questions like the ones below while writing a medical biochemistry exam and you immediately go completely blank & scared
QUESTION 1
A 28yr old final year student went on an empty stomach to the gym this morning to workout. After working out for up to 2 hours, he decided to take a drink. Instead of drinking water, he drank up to 3 bottles of an alcohol containing drink. Few minutes after that he slumped and died. Putting the incident surrounding his death into consideration, What could have been the cause of his death?
QUESTION 2
Mr Amadi is a 65 year old farmer who produces garri for a living, Who was rushed in to the emergency unit this morning with a blood pressure of 190/120 mmHg. The house officer on call quickly gave a IV Nitroprusside (but gave it quickly).
A.What possible complications may result from the quick administration of Nitroprusside
B. What part of the Electron Transport Chain would be affected by the complication
C. What drug must he give as follow up to reduce the potential complications?
Don't worry! these are actually very simple questions to solve if you're well taught to understand the basic concepts of medical biochemistry.
Let me introduce myself. My name is Dr Onos, I'm a medical doctor and a medical biochemistry tutor/coach at TAVAcademy, I will like to take you through a journey that'll simplify medical biochemistry for you and give some clinical applications to medical biochemistry.
In this course, we will be reviewing multiple choice questions in medical biochemistry. We will start with some topics in general biochemistry then enter into the metabolism of some biomolecules.
The topics in general biochemistry will include ;
Enzymology
Carbohydrates chemistry
Lipid chemistry
Nucleic acid chemistry
Amino acid chemistry
Vitamins
Protein structures
Method of isolation and identification of proteins (protein purification)
Topics to consider under the metabolism of biomolecules will include;
Carbohydrates metabolism
Fat and Lipid metabolism
Amino metabolism
Heme metabolism
Nucleotide metabolism