Medical Biochemistry: Metabolism of Heme & Nucleotides

In this course, we will start our journey with the story of iron metabolism to how heme is synthesized and broken down, then take a look at Nucleotide synthesis and degradation with clinical correlate. To teach this in a very interesting manner, we have divided this course into seven (7) sections with about twenty-four (24) lecture videos all together

This course consists of twenty-four (24) lectures divided into 7 sections:

• Heme Synthesis and Disorders

  • Iron Metabolism

  • Iron Metabolism Disorders

  • Heme Synthesis

  • Heme Synthesis Disorders 1

  • Heme Synthesis Disorders 2

• Hemoglobin and Disorders

  • Globin Chains

  • Hemoglobin

  • Methemoglobin and Carboxyhemoglobin

  • Hemoglobinopathies

  • Sickle Cell Disease

  • Thalassemias

• Heme Degradation and Bilirubin Metabolism

  • Hemolysis & Heme Breakdown

  • Bilirubin Metabolism

  • Hyperbilirubinemia and Jaundice

• Clinical Case MCQs on Heme Metabolism

  • MCQs 1

  • MCQs 2

• Purine Nucleotide Metabolism

  • Overview

  • Purine Nucleotide De Novo Synthesis

  • Regulation and Clinical Correlates of Purine Nucleotide Synthesis

  • Purine Degradation and Salvage Pathway

  • Hyperuricemia and Gout

  • Other Clinical Correlates

• Pyrimidine Nucleotide Metabolism

  • Pyrimidine De Novo Synthesis & Regulation

  • Ribonucleotide Reductase & Oher Enzymes

  • Orotic Acidurias

  • Pyrimidine Degradation & Salvage Pathway

• Clinical Cases on Nucleotide Metabolism

  • Clinical MCQs on Nucleotide Metabolism

We will also consider some clinical Multiple Choice Questions Review as it relates to Heme metabolism and Nucleotide Metabolism.