Learn Bioinformatics From Scratch (Theory & Practical)

Name: Learn Bioinformatics From Scratch (Theory & Practical)
Rating: 4.5 (2977 reviews)

Best Bioinformatics course for Students, Academia and Industry Professionals to learn Bioinformatics and biological data

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Created byNaeem Mahmood Ashraf

Last updated 6/2026

English

What you'll learn

You will learn Basic Theory & Practical demonstration of Bioinformatics tools
You will learn how to explore databases, and align sequences (Pairwise and Multiple Sequences)
You will learn theory and practical to predict Genes and their regulatory elements
You will have good understanding about homology modeling for 3D structure prediction (Theory & Practical)
You will learn 3D structure Prediction using Threading Algorithm (Theory & Practical)
Secondary Structure Prediction of Globular and Transmembrane proteins (Theory & Practical)
Receptor-Ligand Docking and Analysis of Docking Data (Practical)
Phylogenetic tree (Theory)
Construction of Phylogenetic tree in (Practical)
This basic Bioinformatics course will laydown very strong foundation for their future learning.
We claim that so far there is not any comprehensive course like this on Udemy.

Course content

6 sections • 107 lectures • 8h 26m total length

Definition of Databases2:32
Database Design4:57
Knowledge Discovery1:06
Biological Databases2:46
Take Home Key Points1:05
Practical -1: NCBI Nucleotide Database12:57
Practical-1.2: ENSEMBLE Genome Browser6:47
Practical-2: Protein Databank (PDB)12:11
Quiz 1
Assignment 1
Recent Update About Protein Databank4:32
Searching the Sequences in Databases

What is Sequence Alignment?3:27
Some Important Terms2:58
Types of Sequence Alignment3:46
What is Algorithms?1:59
Dot Matrix Algorithm; How Does It Work?2:28
Dot Matrix Algorithm; How to Interpret The Results?1:50
Dot Matrix Algorithm; Identification of Repeat Sequences1:18
Dot Matrix Algorithm; Advantages Vs Disadvantages1:39
Practical-3: Dot Matcher for Qualitative Comparison of Sequences (EMBOSS Tool)7:10
Practical-3 (Optional): DotMatcher for Qualitative Comparison of Sequence8:12
This is old video of the course. This dotmatcher too is still available. But we will recommend you to use our new EMBOSS dotmatcher.
Assignment 2
Dynamic Programming Method: How Does It Work?5:27
How to Transform Scoring Matrix to Alignment?5:40
Dynamic Programming; Some Important Terms to Understand1:18
Comparison Between DotMatrix and Dynamic Programming2:11
Practical-4: Global Pairwise Sequence Alignment Using DNA Sequences5:44
Practical-5: Pairwise Sequence Alignment Using Protein6:24
Practical-6: Local Pairwise Sequence4:57
Assignment 3
Introduction to Database Searching; BLAST2:49
Type of Algorithms3:41
How Does Word Algorithm Work? (Part-1)1:04
How Does Word Algorithm Work? (Part-2)3:18
A Important Term For Word Algorithm1:36
Important Statistical Values to Evaluate the BLAST Results5:00
Different Type of BLAST Associated with NCBI Databases2:06
Practical -7: How to Use BLAST Program10:29
Assignment 4
Optional: How to Use PSI-BLAST6:16
Multiple Sequence Alignment; An Introduction1:24
Algorithms for Multiple Sequence Alignment1:29
Progressive Sequence Alignment Algorithm5:30
Tools for Multiple Sequence Alignment2:15
Practical -9: How to Use T-COFFEE7:38
Practical -8: How to Use CLUSTAL-W3:34
Assignment 5
Quiz 2
Explain Your Junior What you have Learned of Sequence Alignment

Introduction of Module 32:05
What is DNA?2:06
Where Is Our DNA is Located?0:53
What Is Role of DNA?3:13
What Does Gene Have?5:15
Algorithms for Gene Prediction-17:16
Algorithms for Gene Prediction-21:46
GC-Bias and Test Code; An Ab-initio Type of Algorithm2:24
Introduction of Markov Model (Part-1)1:52
Introduction of Markov Model (Part-2)1:52
Machine Learning and Gene Prediction2:21
Practical-10: Prediction of Prokaryotic Gene11:32
Assignment 6
Practical-11: Prediction of Eukaryotic Genes5:45
Assignment 7
What is Sanger Sequencing to Sequence the DNA?2:19
Sanger Sequencing Data and Issues3:30
Practical-12: How Check Quality of Sanger Sequencing Data?4:27
Quiz 3

Introduction of Module 42:43
What is Protein? (Part-1)2:55
What is Protein? (Part-2)2:50
Some Important Points2:29
Role of Amino Acids in 3D Structure3:16
Peptide Bond; A link between Amino Acids1:14
Double Bond like Character in Peptide Bond & Ramachandran Plot2:29
Forces Stabilizing The Protein Structure2:41
Secondary Structures of Proteins4:29
Practical 13: Visualization of Protein Structure in Pymol7:27
Practical 13(A): Visulization of Protein Structure in Chimera (Part-1)7:57
Practical 13(B): Visulization of Protein Structure in Chimera (Part-2)8:29
Why Protein Structure Prediction is So Important?2:28
Protein Secondary Structure Prediction Algorithms (Part-1)2:10
Protein Secondary Structure Prediction Algorithms (Part-2)7:25
Practical-15: Prediction of Globular Protein Secondary Structure4:59
Assignment 8
Algorithm for Secondary Structure Prediction of Transmembrane Proteins3:10
Practical-16: Prediction of Transmembrane Helix Secondary Structure4:16
Assignment 9
3D Structure Prediction Algorithms3:48
Homology Based Algorithm (Part-1)2:53
Homology Based Algorithm (Part-2)3:36
Homology Based Algorithm (Part-3)2:12
Homology Based Algorithm (Part-4)2:15
Model Validation & Draw back of Homology Based Algorithm2:30
Practical-17: Prediction of 3D structure Using Homology Modeling (Mdeller)28:16
Please use the following files and python scripts to develop the 3D structure of your protein using Modeller. The detailed procedure to use these files is demonstrated in the video tutorial. Please watch the tutorial and make the necessary changes as per your own need. We have tried our level best to make these files error-free. In case of any error please immediately let us know, we will try to correct it and upload it again.
Script1.py will be used to analyze your query protein sequence
Script2.py will be used to select the most appropriate template for model development
Script3.py will be used to develop alignment between the query sequence and template sequence.
Script4.py will be used to develop backbone, loop and R-chain modelling.
Script5.py will be used to optimize the model by using the energy function.
For more details, please watch the practical tutorial and theory lectures.
Please also make sure that you run the modeller with all administrative privileges. For information, please see the attached figure.
Assignment 10
Threading Algorithm for 3D Structure Prediction2:09
Practical-18: Prediction of 3D structure Using Threading Technique (I-TASSER)11:16
Assignment 11
(Very Important) Practical Learn How to Use Alpha-Fold 24:47
Please use the following link to access the alpha-fold2 Colab to make a 3D structure prediction for Free.
https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/AlphaFold2.ipynb
Practical Learn How to Use Alpha-Fold312:37
Assignment 12
How to Make Publication Quality Images In Pymol? (Very Important)11:55
Quiz 4
(Optional) Practical-18.1: Use of InterPro5:24
(Optional) Practical-20: How to Perform Docking Easily Using Vina6:39
(Optional) Practical-21: How to Analyze the Docking Data11:43
(Optional) Practical 3: ZINC Database for Drug Searching8:59
Update Another GOR-IV Server for Secondary Structure Predictions2:53
Dear Students,
Please have a look at another GOR-IV server which you can use to make secondary structure predictions of globular proteins. You can access this server for free of cost using https://npsa-prabi.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_gor4.html.

What is Evolution and Phylogenetics2:20
Some Important Terms To Understand Phylogenetic Tree2:46
Different Type of Phylogenetic Trees1:45
Steps To Construct Phylogenetic Tree1:46
Selection of Molecular Marker for Tree Construction3:50
Alignment for Tree Construction1:12
Evolutionary Model Selection5:34
Methods To Construct Tree3:57
Validation of Tree By Bootstrapping1:53
Practical -19: Building Phylogenetic Tree7:56
Assignment 12
Practical-19.1: Building Beautiful Circular Phylogenetic Tree13:24
Quiz 5

Requirements

In online teaching, it's always hard to engage the students. Therefore we have designed this course keeping the psychology of students in view. Usually, students start to lose their interest when they are stuck in a complex concept that's why We tried to move from simple to complex easily and understandably.
You need to know about the very basics of Biological macro-molecules. Do not worry if you do not know the details. For instance, if you just heard the name of DNA, RNA and Proteins and have a basic idea about their roles in life then it's enough for you (School Level Information). You are welcome to this course. In every module of this course, we will take start from very scratch. We will assume that you know nothing about DNA, RNA, and Proteins except their names. We hope this technique will make it easy for you to understand the hardcore concepts of bioinformatics in a better way.
This is no coding in this course. Most of tools which we will use that's available online For Free without Sign Up

Description

This Bioinformatics course is going to game changer for you. Currently, there is an explosion of biological data. You need to develop your skills to handle the data in the era of this big biological data. It is humanly impossible to tackle the high biological data using conventional techniques. Here comes Bioinformatics. Bioinformatics is at the intersection of biology and computer science. Without this basic skill, you may not stand anywhere in research, academia and industry in the coming five to ten years. Keeping this need of time in view, we brought here a basic bioinformatics course for you.

This course includes five modules

(1) Databases

(2) Alignment

(3) Genomic Bioinformatics

(4) Structural Bioinformatics

(5) Evolutionary Bioinformatics

This course is a unique blend of theory and practical. You will learn basic theory then perform practical and afterwards attempt the quizzes to check your knowledge. There is a total of 93 Lectures among them, there are 19 practical tutorials. Furthermore, there are 12 Assignments and 5 quizzes in this course along with theory lectures. We assure you that after taking this course, your perspective will be very different for biological data. Students will learn the basics of bioinformatics, starting from biological databases to protein-ligand docking. There will be variety of the bioinformatics tools that we will use. These tools are freely available and closely related to the course material, and students will need to sign up for some tools to access them but for most of tools there will be no need to sign up.

We hope this course will be worth your money and time.

Who this course is for:

Beginners from Biological sciences
Data Science beginners who are interested in biological data

Learn Bioinformatics From Scratch (Theory & Practical)

What you'll learn

Explore related topics

Course content

Module 1 Databases10 lectures • 49min

Module 2 Sequence Alignment33 lectures • 2hr 5min

Module 3: Genomic Bioinformatics16 lectures • 59min

Module 4: Structural Bioinformatics35 lectures • 3hr 17min

Module 5: Evolutionary Bioinformatics11 lectures • 46min

Module 6 (Optional)4 lectures • 30min

Requirements

Description

Who this course is for: