Introduction to Pharmaceutics and Biopharmaceutics

In this lesson, I will explain what solution, dissolution, and solubility are. I will also explain and provide examples of the different solution types, and what factors may affect solubility.

In this lesson, I will briefly introduce the various methods for testing solubility. For more technical information about the different methods, see the resource section.

In this lesson, I will discuss the advantages, disadvantages, and the components of a solution. This sets the foundation on why pharmaceutical scientists may pick solutions or other form as the final dosage form.

In this lesson, I will provide detail descriptions and roles of each component in a solution. I will also briefly explain important theories, such as pH, concentration gradient, tonicity, and preservatives.

In this lesson, I will define what rheology, viscosity, and fluidity are. I will also explain the various types of viscosity.

In this lesson, I will explain the different types of Newtonian and non-Newtonian fluid, along with their examples and real-life applications.

In this lesson, I will describe what is a dispersion and explain in detail about the various types of dispersion systems.

In this lesson, I will describe the basics of microbiology, provide a brief history of vaccine and pandemics, and talk about a common and regulated practice known as Good Manufacturing Practices (GMP).

In this lesson, I will define what sterilization is and talk about dry and wet heat sterilization methods.

In this lesson, I will explain what chemical, radiation, and filtration sterilization methods are.

In this lesson, I will explain a real-life application of the sterilization method, known as pasteurization, and its process.

In this lesson, I will discuss the benchmarks for sterilization, such as decimal reduction time, Z-value, F-value, and equivalent treatment. This lesson is a bit math heavy, but you don't have to worry too much about the derivations if you're not interested.

In this lesson, I will discuss the various factors that affect drug stability, and what are some ways we can address drug stability concerns.

In this lesson, I will explain the advantages and disadvantages of solid dosage forms, how it relates to bioavailability and particle properties. This is a very important lesson, as it lays the foundation for the rest of this section.

In this lesson, I will discuss the concept of particle dissolution and how the Noyes-Whitney equation play a role in it. This is a very important equation. Though I will not dive into the details of the math and derivation, but the theory behind how dissolution affects drug particles.

In this lesson, I will discuss the common methods for determining particle size, including the sieving, sedimentation, microscopy, laser light, and coulter counter method. Apologies for this particularly long lesson, please take breaks as needed!

In this lesson, we will see the importance of determining particle shape and the two methods of determining a particle's shape.

After this lesson, you will define density and porosity with relation to particles. We will also discuss methods of determining particle density and the various types of density.

In this lesson, I will explain what flowability is, and why it is important in the context of manufacturing. I will also describe the methods used in determining flowability.

In this lesson, I will explain what wettability and compressibility are, and why they are important in the context of manufacturing. I will also describe the methods used in determining wettability and the mechanism behind powder compression.

In this lesson, I will outline the steps and methods of preparing powders. In addition, I will explain the theory behind powder mixing and their degree of mixing.

In this lesson, I will discuss the science of solid dosage forms. Specifically, I will breakdown the properties, such as structure, melting point, solubility, bioavailability, and stability. I will also explain the concept of polymorphism and eutectic mixture.

In this lesson, I will describe the process in which substance (e.g. food or drugs) travel throughout our gastrointestinal (GI) tract. I will also dive into how we absorb drugs and what factors within our body that may affect their bioavailability.

In this lesson, I will define metabolism and briefly explain how it affects the drug we take. In addition, I will discuss the theory of drug concentration increases or decreases as a function of time.

In this lesson, I will explain the concept of therapeutic window. In addition, I will provide real-world examples to show the importance of adhering to the therapeutic window.

In this lesson, I will explain why we take multiple doses, the concept of steady-state, and the effect of dose frequency and size. In addition, I will describe the theory of half-life and how it relates to dosage regimen.

In this video, I will provide a quick overview of the manufacturing of solid dosage forms.

In this lesson, I will talk about the advantages and disadvantages of powder and granule as the final dosage form. I will then dive into the two types of granulation and the manufacturing process of making granules.

In this lesson, I will explain the process of tablet making (compression) from granules. I will also outline the criteria for what makes a good tablet, and the various types of tablet.

In this lesson, I will briefly talk about why we coat tablets. We won't dive into the process of coating tablets are it is outside the scope of this course.

In this lesson, I will describe the process of encapsulation and show videos of manual, semi-automatic, and automatic machines at work.

You did it! CONGRATULATIONS!! You have finished this course. Don't forget to get your certificate. I sincerely wish you the best in all your future endeavors and thank you again for taking this incredible journey with me.

And if you're interested, feel free to check out my other course on Udemy called "Introduction to Drug Discovery and Drug Development".