Introduction to drug development and discovery

In this lecture, you'll have an overview of how in vitro experiments are carried out in the context of infectious diseases

In this lecture, you'll have an overview of how in vitro experiments are carried out in the context of cancer

In this lecture, I explain how biological activity can be measured in some in vitro experiments by using two examples of techniques: colorimetric assays and fluorimetric assays

In this lecture, I describe two additional ways to quantify biological activity in in vitro studies: antibody-based assays, and microscopy-based analysis

Hi! In this lecture, we will talk about endpoints of biological activity in in vitro experiments, such as IC50, EC50, CC50 etc...

In this lecture, I present a brief overview about biochemical assays in the context of drug discovery and why they are relevant

In this lecture, I present an overview on in silico (or virtual) studies and their advantage for drug discovery

In this lecture, you'll have an overview of molecular docking , a virtual technique used to accelerate the discvery of hits in the early process of drug discovery

In this lecture, I briefly introduce the computational toxicity and pharmacokinetic, and how softwares usually estimates these parameters by "looking" at the structure of a molecule

In this lecture, we'll have a very brief overview about Molecular Dynamics, which is a powerfull technique used in the context of virtual studies!

In this lecture, you'll have an overview of the principles and general concepts of animal experimentation

In this lecture, I introduce the concept of pharmacokinetics and explain the relevance of administration and distribution for drug design

In this lecture, I explain why liver metabolism and excretion must be taken into account when developing drugs

In this lecture, I explain the main advantages of rodent models for drug discovery and the main types of rodents used in biomedical research

In this lecture, we'll see how biological activity can be measured/quantified in experiments

In this lecture, you'll have an overview of clinical studies and how they are conducted

In this lecture, you'll have an overview of Phase I clinical studies and how they are conducted

This lecture summarizes the main steps taken in Phase II of clinical trials when compared to those of Phase I

In this lecture, we explore the main features of the phase III of clinical trials, which is the last phase of clinical research befpre approval by a regulatory aggency

In this lecture, I explain what makes Phase IV different from other phases of clinical research

In this lecture, I present specific differences of clinical studies in the context of cancer

In this lecture, I present specific differences of clinical studies in the context of Infectious diseases

In this lecture, you'll have an overview of the process of vaccine development

In this lecture, you'll know the main types of vaccines traditionally used in the process of vaccine development

In this lecture, you'll know the modern approaches used in the process of vaccine development

This lecture summarizes the main steps taken in Phase I of clinical trials for vaccines

This lecture summarizes the main steps taken in Phase II of clinical trials for vaccines

This lecture summarizes the main steps taken in Phase III of clinical trials for vaccines

In this lecture, I describe a new approach (relatively speaking), which is an improvement over traditional 2D in vitro systems to evaluate drug interactions, physiological processes and toxicology