
Explore the biology of aging, including lifespan, healthspan, and cellular and molecular senescence, and learn about common lab practices and evaluating anti-aging claims with rigorous research.
Explore the structure of the course, why we study aging, and the mechanisms behind aging. Discover approved treatments to delay aging, ongoing trials, animal-model research, and future translational perspectives.
Explore how aging arises from primary hallmarks like genomic instability and telomere attrition, driving cellular senescence and SASP. Examine how dysbiosis, chronic inflammation, and mitochondria contribute to healthspan and lifespan.
Quantify cellular senescence to study aging using beta galactosidase staining (x-gal) and markers like p21, p16, Lamin B1, gamma x, and il one beta, with automated confocal microscopy.
Explore how telomere attrition drives senescence, the roles of shelterin and telomerase, and alternative lengthening mechanisms, then evaluate methylation clocks and partial reprogramming for anti-aging strategies.
Compare anti-aging drugs in clinical trials, including rapamycin, metformin, nicotinamide mononucleotide, spermidine, and senolytics, and assess their effects on autophagy, healthspan, and lifespan.
This lecture covers senolytics like fisetin and quercetin that kill senescent cells, anamorphics that delay their formation, and berberine's potential in trials to extend lifespan.
Explore anti-aging strategies beyond drugs, including caloric restriction and intermittent fasting, and examine lifespan interventions from parabiosis, young blood components, and epigenetic reprogramming, with human trial status and safety considerations.
Why do we age? Which biological mechanisms has humanity evolved to have one of the longest lifespans in the animal kingdom? Can our current technological progress extend our lifespan and healthspan by decades or even centuries?
If you're interested in these topics, whether you have a Ph.D. in life sciences, you are a university student in biology or medicine, or simply an enthusiast with a basic understanding of biology, this is the right course for you!
Be wary of courses on aging topics taught by people without academic credentials and self-proclaimed experts. By choosing my course, you are opting for high-quality information and will be able to easily navigate through the jungle of fake news that unfortunately surrounds this subject today.
I am Dr. Gabriele Morabito, I have studied the mechanisms regulating aging in vertebrates at the best aging biology centers in Europe (MPI age of Cologne and FLI of Jena), moreover I have personally tested cutting-edge diagnostic techniques and potential anti-aging therapies in animal models.
Recently I won a Post-doc fellowship with "Impetus for Longevity" and I'm currently working as an aging scientist at the University of Pisa, in Italy. Since this year I'm also part of the "Longevity Nexus" community through which I'm weekly in contact with top-level experts on the aging field around the world.
Despite my young age, I am an expert in the aging field and I would like to share my knowledge with anyone interested in the subject, aiming to create an ever-growing community dedicated to finding solutions to contrast human aging and who knows... maybe one day, even stop aging completely!
What are you waiting for? Get your certificate on this course and join a community of experts in the aging field!!