Intro to Clinical Pharmacology: Dynamics and Kinetics

Explore how pharmacodynamics shapes drug effects by examining mechanism of action, efficacy, potency, receptor subtypes, and how geriatric physiology alters drug responses, with real-world clinical examples.

Explore how pharmacokinetics—absorption, distribution, metabolism, and elimination—plus bioavailability, routes of administration, volume of distribution, half-life, and drug interactions determine dosing and patient outcomes.

Analyze elimination, renal function, and drug exposure, including GFR and creatinine clearance, and how steady state, half-life, and drug interactions shape pharmacokinetics.

Explore how aging alters pharmacokinetics, including reduced GI motility and gastric acid affecting iron absorption, shifts in lipophilic drug distribution, and declining renal and hepatic function.

Identify how mechanism of action and receptor subtypes influence drug effects, recognize duplicate therapy, and anticipate adverse effects in the elderly by considering renal function, interactions, and absorption.