Insulin synthesis and secretion

Name: Insulin synthesis and secretion
Rating: 4.8 (9 reviews)

Learn Insulin with the World's Most Popular Medical Teacher. Crystal clear concepts with hand-drawn illustrations.

Created byDr. Najeeb Lectures

Last updated 7/2019

English

What you'll learn

Insulin synthesis & secretion.
Insulin receptors and transduction Pathways.
Summary of insulin receptor and signaling pathway.
Metabolic effects of Insulin on carbohydrates.
Role of insulin in lipogenesis and fat storage.
Lipolysis & ketogenesis in severe insulin deficiency.
Insulin and serum K+ levels.

Course content

6 sections • 18 lectures • 20h 0m total length

Insulin Synthesis & Secretion Part 155:15
1. Synthesis of insulin.
2. Storage of insulin
3. Releasing of insulin.

4. Regulation of insulin.
a) Exocrine function of pancreas.
b) Islets of Langerhans. (structure).
c) Alpha, beta, delta and PP cells. Location in islets of Langerhans.
d) Beta cells secretion. (insulin + c-peptide) amylin and proinsulin)
e) Alpha cells secretions. (glucagon)
f) Delta cells secretion. (somatostatin).
g) Paracrine effect in islet of Langerhans.
h) Blood circulation through islets of Langerhans.
i) Synthesis of insulin.
j) Preproinsulin.
k) Proinsulin
Insulin Synthesis & Secretion Part 244:31
1. Sensory system for synthesis of insulin.
2. G-binding protein on the surface of beta cell. (glucose transporter type II)
3. GLUT-2.
4. Action of glucose kinase action on glucose.
5. TCA and production of ATP’S in beta cells.
6. ATP sensitive K+ channel. Regulation.
7. Ca++ channels and role in releasing of insulin by exocytosis.
8. Drugs acts on ATP sensitive K+ channels.
a) Sulphonyl urea.
b) Meglitinides.
9. Dioxide role in insulin secretion by acting on ATP sensitive K+ channel.
10. Concept of Insulinoma.
Insulin Synthesis & Secretion Part 333:21
1. Brief revision of insulin synthesis and releasing into extra cellar fluid.
2. GIT wall release incretins (peptides) that increase releasing insulin.
3. Functions of incretins.
4. Action of Exenatide. (brief mechanism)
5. Sitagliptin pharmacological effects.
Insulin Synthesis & Secretion Part 431:54
1. Hormones that influence on secretion of insulin.
2. Glucagon receptor on beta cells and its function.
3. Cortisol effect on insulin production.
4. GH effect on insulin releasing.
5. PNS acetylcholine role in releasing insulin.
6. SNS, nor adrenaline effect on insulin production.
7. Somatostatin role in inhibiting insulin.
8. Some important facts about C-peptide.
9. C-Peptide is the better marker to check beta cell function.
10. Differences between type 1 and type 2 diabetes mellitus.
11. Differences between human insulin, pig insulin and cow insulin.
12. Exogenous insulin characteristics.
13. C- peptide biological action.
14. C-peptide importance in diabetic mellitus management.

Insulin Receptors and Transduction Pathways Part 139:24
1. Introduction.
2. General concepts about insulin;

i) What is insulin?
ii) Insulin synthesis.
iii) Role of insulin.
iv) Insulin regulation.
v) Islet of Langerhans.
vi) Types of cells inside islet of Langerhans.
vii) Releasing of insulin (Brief mechanism.)

3. The action of insulin.
4. Structure of insulin receptor.
5. Autophosphorylation of Beta subunits of IR.
6. Tyrosine kinase receptors.
Insulin Receptors and Transduction Pathways Part 21:02:57
Insulin Receptors and Transduction Pathways Part 31:20:21
Insulin Receptors and Transduction Pathways Part 41:50:13

Insulin and serum K+ levels Part 157:56
Role of Na+ - K+ ATPases.

1. Introduction.

2. Normal values of serum K+.

3. How body regulate K+ level.

4. Role of Kidneys in maintaining serum K+ levels.

5. Post-prandial insulin importance to regulate K+.

6. Molecular mechanism of shifting K+ into intracellular compartment.

7. Insulin receptor and PI3K/AKT pathway.

8. Effect of insulin on Na+ - K+ ATPases.

9. Role of protein phosphatases.
Insulin and serum K+ levels Part 21:12:56
1. K+ levels clinical correlates.

a) In type 1 DM.

b) Pathophysiology of DKA. ( brief mechanisms).

c) Principle of management of DKA with hyperkalemia, normal serum K+ level and hypokalemia.

2. Hyperkalemia.

a) Acute renal failure.
b) Extensive tissue injury ( breakdown).
c) ECG changes during hyperkalemia.
d) Importance of calcium gluconate.
e) Drugs used to manage hyperkalemia.

Requirements

All lectures are delivered in English using hand-drawn illustrations on a traditional whiteboard.

Description

Dr. Najeeb Lectures are the World's Most Popular Medical Lectures.
Dr. Najeeb has been teaching medical sciences for over 32 years and has helped millions of students master Medical Sciences with crystal clear concepts. Don’t forget “Lasting Knowledge results from clear concepts.”
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Great for USMLE Step 1 – COMLEX – NBDE – NCLEX – PANCE exams.

Master Insulin synthesis & secretion with Dr. Najeeb. Over 100 hours of videos with thousands of hand-drawn illustrations and crystal-clear concepts. This course will completely change how you look at Insulin synthesis & secretion, and we guarantee you that by the time you finish this course with us, you'll feel like a professional.

We use hand-drawn illustrations to empower your learning process because we believe lasting knowledge results from clear concepts. Our videos are interactive and fun to watch, so you don’t have to spend hours memorizing.

This course includes the following lectures:

1) Insulin synthesis and secretion

2) Insulin receptors and transduction Pathways.

3) Summary of insulin receptor and signaling pathway.

4) Metabolic effects of Insulin on carbohydrates.

5) Role of insulin in lipogenesis and fat storage.

Who this course is for:

Medical student
Doctor
Physicians
Physician Assistant
Dentist
Pharmacist
USMLE Step 1
Paramedics
Osteopathic
Nurse

Insulin synthesis and secretion

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