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Genome Stability in Precision Medicine Course
Rating: 4.8 out of 5(2 ratings)
10 students

Genome Stability in Precision Medicine Course

Sources of DNA Breaks, Breaking and Sealing the Genome - a question of balance (3 Case Studies), Precision Medicine
Created bySherif El-Khamisy
Last updated 4/2023
English

What you'll learn

  • Obtain fundamental information of endogenous and exogenous sources of genomic instability
  • Learn the various types of genomic instability and mechanisms of fixing DNA breaks
  • Critically apply their understanding to different scenarios including clinical case studies
  • Critically understand the experimental approaches used to capture the evidence.
  • Harness this knowledge to devise more effective and precise therapeutics

Course content

3 sections • 6 lectures • 5h 9m total length

  • Introduction - Finding the Sources and Forms of DNA Breaks49:58

    This course begins with a series of classes illustrating the diverse nature of genomic breaks, the good, the bad and the ugly.

Requirements

  • Basic biology knowledge, no programming or bioinformatics experience required

Description

This course is designed for physicians and biomedical scientists engaged in genetics and genomics. We still cannot read and fully understand the nucleotides of an entire genome as you would read a book from beginning to end. Biologists still think our genome is stable, yet the evidence shows that it suffers from breaking and sealing all the time. There are approximately 10,000 DNA breaks per cell per minutes. Breaking and sealing the DNA is a fine balance, which if lost leads to diseases such as neurological disorders and cancer.

To design new therapeutics in a more precise manner, it is critical to be able to read and understand the composition of the entire genome and how cells ensure that this sequence remain the same during the lifetime of a cell or an organism. In this course, we will see how our genome is kept stable, techniques to read and understand its instability and the consequences they might have on human health. The ultimate outcome is to enable a thorough understanding of the principles of precision medicine to improve health outcomes.


Learning Outcomes:

· Obtain fundamental information of endogenous and exogenous sources of genomic instability

· Learn the various types of genomic instability and mechanisms of fixing DNA breaks

· Critically apply their understanding to different scenarios including clinical case studies

· Critically understand the experimental approaches used to capture the evidence.

· Harness this knowledge to devise more effective and precise therapeutics



Who this course is for:

  • This course is designed for physicians and biomedical scientists engaged in genetics and genomics. We still cannot read and fully understand the nucleotides of an entire genome as you would read a book from beginning to end. Biologists still think our genome is stable, yet the evidence shows that it suffers from breaking and sealing all the time. There are approximately 10,000 DNA breaks per cell per minutes. Breaking and sealing the DNA is a fine balance, which if lost leads to diseases such as neurological disorders and cancer. To design new therapeutics in a more precise manner, it is critical to be able to read and understand the composition of the entire genome and how cells ensure that this sequence remain the same during the lifetime of a cell or an organism. In this course, we will see how our genome is kept stable, techniques to read and understand its instability and the consequences they might have on human health. The ultimate outcome is to enable a thorough understanding of the principles of precision medicine to improve health outcomes.

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