
Dna carries instructions to make proteins via transcription, where mrna copies a gene in the nucleus and carries the code to synthesize proteins, guided by promoters.
Explore how genetic variation arises from replication errors and mutations, creating alleles and variants that shape genotypes and phenotypes across individuals.
Explore inheritance patterns in peas, emphasizing dominant and recessive alleles. See how genotype and phenotype relate in homozygous and heterozygous plants, and practice Punnett squares with PKU and Huntington's.
Find publicly accessible next-generation sequencing data on the NCBI SRA, apply filters for exome, DNA, and Illumina, and load runs into Galaxy for processing using FASTA or FASTQ downloads.
Do you want to enter the field of Bioinformatics, but don't know enough about DNA, RNA, and Genetics?
Are you curious about the recent advances in DNA sequencing technology, and how it can be applied to Personalized Cancer Therapy and Disease Research?
Do you want to use Bioinformatics tools to analyze data generated by Next Generation Sequencing?
By the end of this course:
You will have a strong foundation in DNA, RNA, and Genetics
You will have a thorough understanding of Next Generation DNA Sequencing Analysis
You will use a cloud-based platform called Galaxy for the analysis of large datasets
You will assess the quality of raw data
You will use FastQC and Trimmomatic to improve data quality
This course is a starting point in NGS. It covers Biology prerequisites and quality control. Future courses will cover data analysis in more detail.
Project:
This course includes a step-by-step guided project.
This project will assess the quality of raw data from an Illumina sequencer.
You will then use FastQC and Trimmomatic to improve the quality of this data.
Prerequisites:
Biology and Chemistry at high school 10th grade level
Elementary Statistics such as interpreting charts, histograms, and box-and-whisker plots
You must enjoy Biology
This is an introductory course ideal for those with no prior experience in Next Generation Sequencing Analysis.
Enroll today, and launch your career in Bioinformatics.