
You will learn about the drug approval process in clinical trials. Additionally, you will study only effective method for learning pharmacology.
Explore how the liver catalyzes biotransformation through phase one and phase two reactions, using cytochrome p450 enzymes to form active or inactive metabolites and to activate prodrugs.
Explain elimination via biotransformation and renal excretion, distinguish first-order and zero-order kinetics, define half-life and steady state, and illustrate loading and maintenance dosing in clinical practice.
Explore pharmacodynamics by showing how drugs act on receptors—ionic channel, g-protein coupled receptors, intracellular receptors, receptor tyrosine kinases, and non-receptor tyrosine kinases via jak-stat—driving signaling and therapeutic effects.
Explore how drug concentration relates to clinical response, including full, partial, inverse agonists, antagonists, competitive and non-competitive antagonism, physiological and chemical antagonism, and safety metrics like therapeutic index and therapeutic window.
Explore how genetic variants influence drug metabolism and toxicity, covering acetylation, glucuronidation, UGT1A1, TPMT, DPD, VKORC1, G6PD, and HLA associations to tailor pharmacotherapy.
Explore drug safety in pregnancy and lactation, including teratogens, placental transfer, and FDA pregnancy classifications from A to X, with practical contraception guidance.
Welcome to the Fullagonist General Pharmacology course! These lectures are designed to provide medical students, residents, and doctors in training with the essential knowledge and skills required to use the knowledge of pharmacology in their clinical practice.
Here's what you can expect to learn:
First of all, you will learn about the drug approval process in clinical trials. Additionally, you will study, how to approach the subject in order to study well.
In the Pharmacokinetics chapter, you will study how drugs are absorbed, and why does environment has a huge role. how and where are drugs distributed, and how drugs are metabolized and eliminated.
In the Pharmacodynamics chapter, you will learn about types of receptors, examples of their activators, drug-receptor interactions, and the relationship between drug dose and clinical response.
In the Pharmacogenomics chapter, you will learn what is pharmacogenomics, you will understand how genetics influence treatment, how genetics lead to unique side effects, and why a drug may work for one person but not another.
Finally, you'll learn about remarkable pregnancy-related physiological changes, and why your treatment during pregnancy and lactation must be different to avoid a catastrophic outcome - teratogenesis. After this lecture, you will not be afraid of giving a drug to your pregnant patient or nursing mother.
Mamuka Asatiani