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Computational Biology Research - Gene Expression
Rating: 4.4 out of 5(8 ratings)
23 students

Computational Biology Research - Gene Expression

Understand how gene expression research can be used to bring precision medicine.
Created byInhan Lee
Last updated 9/2020
English

What you'll learn

  • Gene expression
  • microarray
  • Disease research in RNA level (example: Parkinson's and Alzheimer's diseases will be used as examples)
  • t-test
  • enrichment testing
  • NCBI tools
  • Gene Ontology
  • Signalling Pathway tools
  • computational biology
  • genetics
  • research skills

Course content

6 sections • 27 lectures • 8h 26m total length

  • Instructor introduction18:30

    Transcription: house-keeping genes and cell-function specific genes

  • Transcription: House-keeping genes and cell-function specific genes28:49

    At the end of the lecture, there are discussion points. Please write your own logical reasons why you choose those genes express in a certain way.

  • Breakout room discussion 1
  • Transcription Factor14:33
  • Breakout room discussion 2
  • Translation: DNA mutation effects on protein14:40
  • Breakout room discussion 3
  • Translation: ribosome and more of expression regulation9:41
  • Breakout room discussion 4

Requirements

  • High school biology class or similar knowledge

Description

This course is designed to facilitate transcriptome research (analyze gene expression data) for people with high school biology-level knowledge. It covers overall transcriptome research that scientists use with application to a disease of focus.

The course covers 1) precision medicine and current biotechnology advances, 2) their implications for our day-to-day health, 3) roles of genes in health and diseases, and 4) the complex influence of daily behaviors on gene functions.

This course emphasizes the impact of real-life environmental factors on and ways in which research can solve certain kinds of problems.

It also covers biology baasics and statistical concepts helpful in doing transciptome research.

Please note that the current version consists of combined lectures from the summer camps we run yearly. This is so that prospective students who want to join our miRcore volunteer programs this school year can take it and join in a timely manner. While the audiences in the lectures are summer campers, the curriculum was prepared as an online course. Please understand some discrepancies in dates and groups in the lectures.

Who this course is for:

  • Students (of any age!) with a love of learning & research
  • miRcore volunteer program candidates
  • Anyone with a broad interest in genetics

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