Chemistry: Structure Drawing Masterclass

Learn to configure default settings in ACD ChemSketch for 2D structure drawing, including a larger page size, ACS style, and atom coloring with grid and palette controls.

Explore drawing aliphatic molecules in ACDChemSketch, starting with methane and advancing to ethane, ethene, and ethyne by adjusting bond order; then build ethanol, methyl amine, dimethylamine, and trimethylamine.

Draw aliphatic molecules from formaldehyde to longer chains, apply substitutions, convert terminal carbons to oxygen or cooh, and build palmitic acid using the draw chain feature.

Draw cyclic aliphatic molecules with ACDChemSketch, including cyclopropane, cyclohexane, and cyclopentane, and apply text, subscripts, superscripts, and substituent features. Explore cyclohexanone, cyclohexenone, alpha beta unsaturation, UV spectroscopy, and Michael reactions.

Master chair and boat representations of cyclohexane using templates in ACDChemSketch, and learn to draw cyclohexane, cyclohexanone, and substituted cyclohexanes like 1-bromo-4-methylcyclohexane.

Learn to draw aromatic molecules using ACDChemSketch, creating benzene derivatives like phenol and aniline. Explore fused rings such as naphthalene and learn to copy structures with square area or lasso.

master lasso selection to isolate closely placed aromatic rings, such as benzene, and explore templates for pentalene, indene, naphthalene, picene, and pyrimidine while adjusting benzimidazole double bonds.

Draw the omeprazole structure using a reference image in the ACDChemSketch workspace, then place a benzene ring, a fused ring, and substitutions with nitrogen and sulfur to match exact conformation.

Master drawing long chain molecules like Vitamin E in ACDChemSketch, using image references, Windows bitmap paste, and wedge-dash bonds to depict tetrahedral geometry and R1, R2, R3 derivatives.

Learn to draw chiral molecules using wedge and dash representations and sketch a polycyclic molecule, and explore Thalidomide's R and S isomers and their contrasting effects on pregnancy health.

Learn to draw chiral molecules by constructing S-thalidomide in ACDChemSketch, placing keto groups and nitrogen and oxygen atoms with correct dash bonds; set up Atorvastatin for next session.

Draw a polycyclic molecule using Atorvastatin in ACDChemSketch, employing chain drawing to place carbons. Add benzene rings, nitrogen, isopropyl, and keto groups, then clean the structure with wedge bonds.

Explore how templates speed up molecular drawing by inserting prepared structures from the template window, including alkaloids, amino acids, aromatics, and carbohydrates like glucose and mannose.

Utilize template features to draw DNA/RNA kits, AMP molecules, antibodies, lipid membranes, DNA replication processes, and reaction symbols; paste into PowerPoint or Word to edit and illustrate.

Learn to use equilibrium arrows to represent keto–enol tautomerism, place equilibrium arrows in the workspace, and interpret arrow lengths that show keto form versus enol form stability.

Learn to draw equilibrium arrows of different lengths in ACDChemSketch by adjusting arrowhead shapes, duplicating arrows, and setting individual heights through object properties.

Learn to draw a reaction scheme with reactants and product, using a reaction arrow and plus sign, and note reaction conditions and reactant details in ACDChemSketch.

Draw the reaction scheme from benzene to benzaldehyde and to benzimidazole, using a plus sign, a reaction arrow, and text notes with HCl, DMSO, 80 degrees Celsius, and 4 hours.

Learn to draw chemical reaction schemes with ACDChemSketch, insert arrows and reaction conditions using text functionality, align reactants like orthophenylenediamine (108 amu), and paste into Word.

Draw a three-component Biginelli reaction scheme using benzaldehyde, ethyl acetoacetate, and urea with ruthenium trichloride catalyst, showing reaction arrows, conditions, and product.

We begin by introducing reaction mechanisms as step-by-step sequences of elementary steps that explain how reactants become products, covering radical mechanisms and examples like benzoin condensation and Buchwald–Hartwig amination.

Explore radical reaction mechanisms, including initiation, propagation, and termination, and learn how fully headed and half-headed curly arrows depict two-electron versus one-electron movements.

Learn how a bromine radical attacks methane to form methyl bromide, and master drawing the reaction in ACDChemSketch by converting to bromine radical, showing lone pairs, and carbon representations.

Draw single-handed curly arrows in the structure panel using a 180-degree arc, adjust arrowheads and colors via object properties, and anticipate fully headed curly arrow mechanisms.

Demonstrate nucleophilic reaction mechanisms with fully headed curly arrows showing two-electron moves, using the Claisen–Schmidt condensation as an example, and guide drawing steps from acetophenone and hydroxide ion in ACDChemSketch.

Master the nucleophilic mechanism drawing using fully headed curly arrows. Visualize oxygen attack, charge shifts, and key steps with benzaldehyde and phenyl fragments.

Explore smiles notation as a 1D string that encodes a molecule’s 2D and 3D structures, illustrated with atorvastatin and PubChem as sources for canonical smiles.

Copy the canonical SMILES, paste into ACDChemSketch, and generate the structure from SMILES to quickly draw beta cyclodextrin and Amphotericin B with clean placement.

Learn how to generate IUPAC names from chemical structures using ACDChemSketch, and understand the unambiguous role of IUPAC names in representing each unique structure.

Learn how to generate IUPAC names from chemical structures using ACDChemSketch, including benzene and aniline, with emphasis on stereochemistry and up to 50-atom molecules; practice naming and applying in research.

Draw benzimidazole in ACDChemSketch and calculate all physical properties. Include molecular formula, composition, mass, and the M+1 peak, then copy results to editor.

Edit a pasted molecule in a word document by double clicking the structure to open ACDChemSketch, modify it, and update the embedded object in the document.

Save your chemistry drawings in multiple formats, including .sk2, .mol, and image formats, and transfer structures between ACDChemSketch and ChemDraw using export options.

Open the answer key for test exercise one and learn to draw aliphatic molecules like n-butyl chloride and chloroacetic acid, then paste into Word and resize using the bottom-right corner.

Practice drawing cyclohexane chair structures with 1-bromo-4-methyl substitutions and assemble hydroxychloroquine with benzene rings, chloro group, nitrogen, and hydroxyl groups using ACDChemSketch.

Learn to draw long chain molecules such as vitamin E by copying from Google, pasting as Windows bitmap into ACDChemSketch, counting carbons, placing substituents and heteroatoms, and adding stereo bonds.

Draw atorvastatin using ACDChemSketch and templates for D-mannose. Apply SMILES to generate structures, draw equilibrium arrows, and illustrate radical or nucleophilic mechanisms, and calculate benzaldehyde properties.

Learn to import a 2D drawn molecule into 3D using the ACD 3D viewer, after sketching in ACDChemSketch, and preview the structure in 3D.

Configure default display settings in 3d viewer by setting white background, balls-and-sticks, and show hydrogens. Save as default and apply 3d optimization to correct bond angles on the water molecule.

Explore molecular representations—wire frame, stick, ball and stick, space fill, and dot representations—and use auto rotate to study geometrical parameters in ball and stick representation.

Master 3D molecule visualization by selecting atoms, rotating in 3D, moving and zooming in the ACD3D viewer, using Atorvastatin as an example to compare 3D and 2D structures.

Learn to capture images from a 3d structure using the acd3d viewer by selecting the whole molecule, copying with Ctrl A and Ctrl C, pasting into Word, and rotating views.

Learn to calculate bond lengths and bond angles in methane and water, using a 3d viewer to measure c–h bond lengths (1.111 angstrom) and h–c–h bond angles (109.454 degrees).

Draw the water molecule, import it into a 3d viewer, optimize it, and calculate the oh bond length of 0.96 angstrom and hoh angle around 104 degrees, illustrating lone-pair repulsion.

Study cis- and trans-1,2-dibromoethene by computing bond lengths and angles during 3d optimization. Compare carbon–bromine and carbon–carbon distances (about 1.873 and 1.34 Å) with literature values, and examine dihedral angles.

Learn to compute dihedral angles, or torsional angles, between two planes using four atoms, and compare cis-1,2-dibromoethene and trans-1,2-dibromoethene to see plane alignment.

Explore module 1 2d structure drawing and module 2 ACD 3D viewer workflows to draw methane and water, and cis-1,2-dibromoethene and trans-1,2-dibromoethene with geometrical values and 3d optimization.