
Explore amino acid chemistry, peptide and amide bonds, and how peptides become proteins, including alpha helix structures and beta sheets. Discover solid phase peptide synthesis to assemble peptides.
Explain enzymatic resolution of amino acids, including acylase-selective hydrolysis of L amino acids, and enantioselective synthesis from achiral alkenes using chiral hydrogenation catalysts to yield single enantiomers.
Explore how amino acids link via peptide bonds to form polypeptide chains, whose primary structure and hydrogen bonds drive folding into alpha helices, beta sheets, and functional interactions.
This course explore the structure, synthesis, and chemistry of these essential building blocks of life. In this comprehensive course, you will explore biomolecules' structure, synthesis, and chemistry.
The primary topics covered in this course are:
1. Amino Acid Synthesis structure and chemistry: The various methods and mechanisms involved in amino acid synthesis. Learn about the different pathways and reactions required to create these fundamental protein building blocks. Understand the importance of stereochemistry in amino acid synthesis.
You will explore the structural features of amino acids, including their backbone, side chains, and functional groups. Gain insight into amino acids' physicochemical properties, such as acidity and basicity. Study the reactivity of amino acids, including their involvement in peptide bond formation and other chemical reactions.
2. Peptides and Polypeptides: Investigate the formation and properties of peptides and polypeptides. Understand how amino acids are linked together through peptide bonds to form these chains. Explore the different types of peptides, including dipeptides, tripeptides, and longer polypeptide chains, and how to separate them. Explain the principles behind these techniques and their application in peptide analysis and sequencing.
3. Protein Structures: Examine the hierarchical levels of protein structure, including primary, secondary, tertiary, and quaternary structures. Understand how the sequence of amino acids determines the folding and conformation of proteins. Explore the forces and interactions that stabilize protein structures and contribute to their unique functions.
By the end of this course, you will have a deep understanding of amino acids, peptides, and protein chemistry. You will be equipped with the knowledge and tools to analyze, synthesize, and comprehend biomolecules. Join us on this exciting journey and unlock the secrets of amino acids, peptides, and proteins!