
Develop acquired immunity, also known as adaptive or specific immunity, after exposure to pathogens in vertebrates. Exhibits specificity, diversity, self and non-self discrimination, and immune memory.
Explore antigens on red blood cells and the ABO system, defining A, B, AB, and O, their surface antigens and antibodies, and universal donor and recipient concepts for blood donation.
Explore anatomical and physiological barriers of innate immunity: anatomical (skin and mucous membranes with stratum cornum, sebum) and physiological (fever, gastric acid, lysozyme, interferons) as first-line defenses.
Explore the phagocytes barrier, where neutrophils and monocytes engulf pathogens and macrophages, including Kupffer cells, protect tissues. Examine the inflammatory barrier, where histamine and prostaglandins raise vasodilation, permeability, and CRP.
The lecture outlines the acquired immune system's two main cell groups—lymphocytes and antigen presenting cells—and how B and T cells mature, circulate, and form specialized immune clones.
Activate B lymphocytes to produce clones of helper T, cytotoxic T, suppressor T, and memory T cells that coordinate antibody production, cell killing, self-attack prevention, and faster re-exposure responses.
Explore the two forms of acquired immunity, active and passive, and their natural and artificial subtypes, with examples like vaccines and maternal antibodies.
Explore cancer as uncontrolled, undifferentiated cell growth that forms tumors; benign tumors stay restricted and surgically removable, while malignant tumors spread via metastasis and can be fatal.
Aids is an immunodeficiency syndrome caused by the HIV virus, a retrovirus with single-stranded RNA and gp41/gp120 glycoproteins, transmitted via unsafe sex, mother-to-child routes, and contaminated blood.
SUMMARY
Health is not just the absence of disease. It is a state of complete physical, mental, social and psychological well-being. Diseases like typhoid, cholera, pneumonia, fungal infections of skin, malaria and many others are a major cause of distress to human beings. Vector-borne diseases like malaria especially one caused by Plasmodium falciparum, if not treated, may prove fatal. Besides personal cleanliness and hygiene, public health measures like proper disposal of waste, decontamination of drinking water, control of vectors like mosquitoes and immunisation are very helpful in preventing these diseases. Our immune system plays the major role in preventing these diseases when we are exposed to disease-causing agents. The innate defences of our body like skin, mucous membranes, antimicrobial substances present in our tears, saliva and the phagocytic cells help to block the entry of pathogens into our body. If the pathogens succeed in gaining entry to our body, specific antibodies (humoral immune response) and cells (cell mediated immune response) serve to kill these pathogens. Immune system has memory. On subsequent exposure to same pathogen, the immune response is rapid and more intense. This forms the basis of protection afforded by vaccination and immunisation. Among other diseases, AIDS and cancer kill a large number of individuals worldwide. AIDS caused by the human immuno-deficiency virus (HIV) is fatal but can be prevented if certain precautions are taken. Many cancers are curable if detected early and appropriate therapeutic measures are taken. Of late, drug and alcohol abuse among youth and adolescents is becoming another cause of concern. Because of the addictive nature of alcohol and drugs, and their perceived benefits like relief from stress, a person may try taking these in the face of peer pressure, examinations-related and competition-related stresses. In doing so, he/she may get addicted to them. Education about their harmful effects, counselling and seeking immediate professional and medical help would totally relieve the individual from these evils.