Basics of Longevity

Explore what aging truly is, how inflammation and longevity genes shape healthspan, and how lifestyle interventions can slow, prevent, or reverse aging to reduce non-communicable diseases.

Explore how genetics and epigenetics shape longevity, from DNA and telomeres to how lifestyle factors - diet, sleep, exercise, and stress - modulate epigenetic switches and aging hallmarks.

Define the nine interrelated hallmarks of aging across core, amplifier, and outer stages, and apply three criteria to guide interventions that improve healthspan and lifespan.

Trace how the amplifier middle circle worsens mitochondrial dysfunction, oxidative stress, and proteostasis loss, triggering inflammation via inflammasomes and deregulated nutrient sensing through mTOR and AMPK.

The origin hallmarks of aging drive cellular dysfunction through genomic instability, telomere depletion, and epigenetic changes; autophagy maintains cellular renewal, with environmental factors accelerating aging.

Explore the outer circle of aging, focusing on cellular senescence, stem cell exhaustion, and altered intercellular communication driving inflammaging and the six longevity opponents.

Learn the six opponents of longevity—metabolic syndrome, cancer, cardiovascular, respiratory, musculoskeletal, and central mental disorders—and how aging hallmarks drive these NCDs, with targeted interventions.

Explore the six most important longevity genes and factors, including mTOR, AMPK, sirtuins, Foxos, parps, and NAD+, and their roles in the nine hallmarks of aging.

Explore the mechanistic target of rapamycin (mTOR) as a longevity gene and how caloric restriction, intermittent fasting, and polyphenols modulate mTOR and autophagy to improve healthspan.

Ampk acts as the body's energy sensor, regulating metabolism, mitochondrial health, autophagy, and inflammation to support aging and longevity, while boosting glucose uptake and fat oxidation.

Discover how NAD+-dependent sirtuins act as guardians of cellular health, enhancing DNA repair, stress response, metabolism, and mitochondrial function to influence aging and longevity.

FoxOs are key regulators of aging and longevity, activating antioxidant defenses, DNA repair, and metabolism while improving insulin sensitivity and cancer suppression.

Discover how PARPs detect DNA strand breaks, repair DNA, and regulate chromatin, epigenetics, and mitochondria via NAD+, reducing oxidative stress, cancer, CVDs, and mental health risks.

Explore how lifestyle factors influence longevity genes and hallmarks, and learn strategies to optimize mTOR, AMPK, sirtuins, FoxOs, and NAD+ to extend healthspan.

Explore aging measurement by separating biological from chronological age and spotting early decline, and tailor longevity plans via a patient questionnaire, consult, measuring NAD+, AMPK, mTOR, and mitochondrial function.

Learn how longevity medicine prevents aging by using personalized, predictive diagnostics and precision therapies to extend healthspan and manage aging hallmarks.

Explore basics of longevity by linking genes and epigenetics to healthspan, aging hallmarks, and factors shaping longevity, through a multi-chapter course for professionals.