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Basics of Immunotherapy: CAR-T, mAbs, and New Modalities
Rating: 4.9 out of 5(7 ratings)
10 students

Basics of Immunotherapy: CAR-T, mAbs, and New Modalities

Master CAR-T, monoclonal antibodies, and next-generation immunotherapies for cancer and immune disorders.
Created bySinjini Bala
Last updated 10/2025
English

What you'll learn

  • Understand the fundamental principles of immunotherapy and its role in modern medicine, including the mechanisms behind CAR-T cell therapy and mAbs.
  • Analyze the development, design, and clinical applications of CAR-T and mAb therapies in treating cancers, autoimmune diseases, and infectious disorders.
  • Evaluate the challenges, side effects, and strategies for improving efficacy and safety in immunotherapeutic approaches.
  • Explore emerging innovations such as bispecific antibodies, oncolytic viruses, nanotechnology-based delivery systems, and AI-assisted immunotherapy design.

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Course content

2 sections • 12 lectures • 1h 43m total length

  • Introduction to Immunotherapy9:36

    1.1 Overview and historical background of immunotherapy

    1.2 Principles of immune modulation in disease treatment

    1.3 Types of immunotherapies: active, passive, and adoptive approaches

    1.4 Advantages, challenges, and scope of immunotherapy in modern medicine

  • Fundamentals of the Immune System9:05

    2.1 Components of innate and adaptive immunity

    2.2 Immune cells and their roles in immune defense

    2.3 Antigen presentation and recognition mechanisms

    2.4 Immune checkpoints and regulation of immune responses

  • Tumor Immunology and Cancer Microenvironment9:17

    3.1 Mechanisms of immune evasion by tumors

    3.2 Tumor-associated antigens and neoantigens

    3.3 Role of cytokines, T cells, and NK cells in anti-tumor response

    3.4 Immune suppression and the tumor microenvironment

  • Monoclonal Antibodies: Basics and Production8:34

    4.1 Concept and discovery of monoclonal antibodies (mAbs)

    4.2 Hybridoma technology and recombinant antibody production

    4.3 Types of mAbs: chimeric, humanized, and fully human

    4.4 Engineering and optimization of therapeutic antibodies

  • Mechanisms and Applications of Monoclonal Antibodies9:59

    5.1 Mechanisms of action: ADCC, CDC, and immune modulation

    5.2 Diagnostic and therapeutic applications in oncology and beyond

    5.3 Approved monoclonal antibody drugs and case studies

    5.4 Limitations, side effects, and resistance mechanisms

  • Introduction to Adoptive Cell Therapy (ACT)9:54

    6.1 Concept and evolution of adoptive cell therapy

    6.2 Types of ACT: TILs, TCR therapy, and CAR-T therapy

    6.3 Principles of ex vivo cell modification and expansion

    6.4 Safety, efficacy, and regulatory considerations

  • CAR-T Cell Therapy: Mechanism and Design7:43

    7.1 Basics of chimeric antigen receptor (CAR) structure

    7.2 Steps in CAR-T therapy: collection, modification, and reinfusion

    7.3 CAR generations and their functional advancements

    7.4 Target selection and tumor-specific antigen recognition

  • Clinical Applications and Case Studies of CAR-T Therapy8:13

    8.1 FDA-approved CAR-T therapies and their outcomes

    8.2 CAR-T in hematologic malignancies vs solid tumors

    8.3 Common side effects: CRS, neurotoxicity, and management strategies

    8.4 Current challenges and approaches for improving CAR-T efficacy

  • Emerging Modalities in Immunotherapy8:22

    9.1 Immune checkpoint inhibitors: PD-1, PD-L1, and CTLA-4

    9.2 Bispecific antibodies and antibody-drug conjugates (ADCs)

    9.3 Cancer vaccines and oncolytic viruses

    9.4 Next-generation immunotherapeutic platforms

  • Immunotherapy Beyond Cancer8:01

    10.1 Applications in autoimmune diseases and infectious disorders

    10.2 Immunotherapy in allergy and transplant rejection

    10.3 Novel immunomodulatory therapies for chronic inflammation

    10.4 Personalized and precision-based immunotherapies

  • Integration of Immunotherapy with Other Modalities7:34

    11.1 Combining immunotherapy with chemotherapy and radiotherapy

    11.2 Role of nanotechnology and biomaterials in immunotherapy delivery

    11.3 Integration with genomics, proteomics, and bioinformatics

    11.4 AI and computational modeling in immunotherapy design

  • Future Trends, Ethical Issues, and Industry Perspectives7:25

    12.1 Recent innovations and next-generation immunotherapies

    12.2 Ethical, safety, and accessibility challenges

    12.3 Clinical trial design and translational research considerations

    12.4 Future outlook and career opportunities in immunotherapy

Requirements

  • This course is designed for beginners, so no prior experience or advanced background in biology or medicine is required. A basic understanding of high-school level biology will be helpful but not essential. Learners only need curiosity and interest in biotechnology, immunology, or healthcare innovations. All key concepts: such as immune mechanisms, CAR-T therapy, and monoclonal antibodies will be explained clearly and progressively throughout the course. No special software or laboratory tools are needed; just a notebook and enthusiasm to explore how cutting-edge immunotherapies are transforming modern medicine.

Description

Immunotherapy is revolutionizing modern medicine, offering groundbreaking treatments for cancer, autoimmune disorders, and infectious diseases. This course, Basics of Immunotherapy: CAR-T and Monoclonal Antibodies, provides a comprehensive introduction to the science, mechanisms, and clinical applications of immune-based therapies. Students will explore the development and production of monoclonal antibodies (mAbs), understand the design and function of CAR-T cell therapy, and examine emerging modalities including checkpoint inhibitors, bispecific antibodies, and oncolytic viruses.

Through detailed explanations and real-world case studies, the course highlights how immunotherapy is applied in oncology as well as beyond, including autoimmune diseases, chronic inflammation, and transplant medicine. Learners will gain insight into the immune system’s fundamentals, tumor immunology, and the principles of immune modulation, providing a strong foundation for both beginners and aspiring professionals in biotechnology, medicine, and life sciences.

The course also addresses practical considerations such as therapy safety, side effects, limitations, and the integration of immunotherapy with chemotherapy, radiotherapy, and cutting-edge technologies like nanotechnology, genomics, and AI-driven design. By the end of the course, students will understand not only how current immunotherapies work but also the exciting innovations shaping the future of immune-based treatments.

Whether you are a student, researcher, or healthcare professional, this course equips you with the knowledge to navigate the rapidly evolving field of immunotherapy and prepares you for further study or a career in biotech, clinical research, or pharmaceutical development.

Who this course is for:

  • This course is ideal for students, early-career researchers, and biotechnology enthusiasts who wish to understand how modern immunotherapies like CAR-T cells and monoclonal antibodies are revolutionizing disease treatment. It’s also highly valuable for medical, pharmacy, and life sciences graduates looking to strengthen their foundation in immunotherapy and explore career opportunities in biotech and healthcare research. Educators, clinicians, and professionals seeking to stay updated with recent advances in cancer immunotherapy and emerging modalities will also find this course insightful and relevant.

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