
APRV only has four primary operator set-points, these include P-High, PLow, T-High, & T-Low.
Secondary settings are the Fio2, trigger, pressurization rate, expiratory termination, & Pressure support.
The P-High setting controls the upper pressure or upper CPAP level. The P-High phase regulates end inspiratory lung volume & is analogues with mean airway pressure.
The T-High Setting controls the time for the upper CPAP level or P-High phase. The T-High provides sustained recruitment, allowing for improved gas exchange by increasing alveolar surface area & exposure time.
The T-Low setting establishes the time interval for the low CPAP phase. This time allows for a intermittent release in airway pressure, which augments PaCO2 removal and off loads the respiratory muscles of the work related to pure CPAP breathing.
Note- T-Low should not be considered as expiratory time, since the patient may exhale throughout the entire P-High phase.
Indications
• PaO2/ FiO2 Ratio < 300.
• Bilateral infiltrates (consistent w. edema, patchy, diffuse).
• No evidence of left atrial hypertension.
Relative Contra-indications
• Serve COPD, emphysema
• Pneumothorax
• Blood pressure: < 90 systolic or < 60 mean
• Unilateral lung disease
Set P-High 2 cmH20 above the measured plateau pressure, from the conventional settings.
T-Low: Based on the “Expiratory Time Constant Measurement”
Setting T-Low based on the expiratory time constant measurement is simple & precise. Set T-low at the same interval as the measured RCexp value.
Rationale- using this measurement sets the T-Low to maintain lung volume at ~ 75% of the Peak Expiratory Flow Rate. This ensures expiratory lung volume & prevents alveolar closure during the release phase
T-Low: Setting Based on the Expiratory Flow Waveform
Titrate T-Low to obtain a “Peak Expiratory Flow Termination Point” (T-PEFR) at 50-75% of the measured “Peak Expiratory Flow Rate” (PEFR).
Rationale- lung mechanics may change which changes the expiratory time constant, T-Low should be reassessed for optimal setting.
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